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KMID : 0191120080230020324
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Journal of Korean Medical Science
2008 Volume.23 No. 2 p.324 ~ p.327
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Central Pontine Myelinolysis in a Patient with Acute Lymphoblastic Leukemia after Hematopoietic Stem Cell Transplantation: A Case Report
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Lim Kyu-Hyoung
Lee Sang-Yoon
Kim Sun-Young
Kim In-Ho
Yoon Sung-Soo
Lim Joo-Han
Yi Hyeon-Gyu
Kim Byoung-Kook
Park Seon-Yang
Kim Ki-Hwan
Kim Jin-Won
Lee Yoon-Su
Rhee Ji-Young
Kim Hye-Jin
Oh So-Yeon
Han Sae-Won
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Abstract
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We describe a 37-yr-old man who developed central pontine myelinolysis (CPM) after allogeneic hematopoietic stem cell transplantation (HSCT) for acute lymphoblastic leukemia. After HSCT, desquamation developed on the whole body accompanied by hyperbilirubinemia. The liver biopsy of the patient indicated graft-versus-host disease- related liver disease, and the dose of methylprednisolone was increased. Then, the patient developed altered mentality with eye ball deviation to the left, for which electroencephalogram and magnetic resonance imaging (MRI) scans were done. Brain MRI scan demonstrated the imaging findings consistent with central pontine myelinolysis and extrapontine myelinolysis. He did not have any hyponatremia episode during hospitalization prior to the MRI scan. To the best of our knowledge, presentation of CPM after allogeneic HSCT is extremely rare in cases where patients have not exhibited any episodes of significant hyponatremia. We report a rare case in which hepatic dysfunction due to graft-versus-host disease has a strong association with CPM after HSCT.
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KEYWORD
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Myelinolysis, Central Pontine, Hematopoietic Stem Cell Transplantation, Graft versus Host Disease
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